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This cytotoxic effect was also reported before; i.e. Natarajan et al. conducted an experiment that found a strong oxidative stress, morphological changes in mitochondria and substantial loss in the fusion of primary hepatocytes exposed to P25TiO2NPs [52].
Titanium dioxide R-5566 can be widely used in indoor and outdoor coatings, latex paints, powder coatings, inks, papermaking, rubber, plastics, masterbatches.
THE OBSCURE HISTORY OF A UBIQUITOUS PIGMENT: PHOSPHORESCENT LITHOPONE AND ITS APPEARANCE ON DRAWINGS BY JOHN LA FARGE